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The growing mechanistic understanding of the microbiota-BA-immune axis offers exciting prospects for novel therapeutic interventions and biomarker development ( Despite these advances, significant challenges persist in translating these complex biological insights into routine clinical practice (127, 164)

Biometals 23, 411417 10.1007/s10534-010-9335-z [DOI] [PubMed] [Google Scholar] Paesano R., Pietropaoli M., Gessani S., Valenti P

Recent studies have demonstrated that secreted frizzled-related protein 4 (SFRP4) is a potential biomarker for -cell dysfunction in type II diabetes, associated with reduced insulin secretion (Bukhari et al., 2019